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. 2016 Oct 7;311(6):H1470–H1484. doi: 10.1152/ajpheart.00500.2016

Fig. 8.

Fig. 8.

PVC genesis modulated by other factors. In each panel, the PVC zone in Fig. 4B was taken as control and colored gray. The PVC zone after a parameter change was colored green. Because the green was set to be semitransparent, the color became darker when the PVC zone overlapped with that of the control. A: normal [LQT2 + the rapid component of the delayed-rectifier potassium current (IKr)]. B: reduced gap junction coupling (from 0.0005 to 0.0001 ms/cm2). C: reduced peak Na current (INa) by reducing the maximum conductance (from 12 to 8 mS/μF). D: hypokalemia [extracellular K concentration ([K]o) changed from 5.4 to 2.7 mM]. E: reduction of inward-rectifier K current (IK1) by 30% (approximately the same reduction of IK1 as in D). F: 10-mV shift to more negative voltages of the steady-state inactivation curve [f in the L-type Ca channel (LCC) model] to suppress window ICa,L.