Table I.
Demographic, clinical and laboratory features of the study groups
| Parameters | Healthy subjects (N = 30) | HD patients (N = 43) | P-value |
|---|---|---|---|
| Female/male* | 15/15 | 25/18 | 0.49 |
| Age [years]** | 59.1 ±10.8 | 64.1 ±11.9 | 0.69 |
| BMI [kg/m2]** | 26.7 ±4.9 | 25.8 ±4.6 | 0.42 |
| Duration of hemodialysis [months] | – | 63.3 ±57.1 | – |
| SBP [mm Hg]*** | 115 (107–120) | 130 (120–140) | < 0.001 |
| DBP [mm Hg]*** | 70 (65–76) | 80 (80–90) | < 0.001 |
| Hemoglobin [g/dl]** | 14.3 ±1.7 | 11.2 ±1.8 | < 0.001 |
| Albumin [g/dl]** | 4.2 ±0.2 | 3.58 ±0.3 | < 0.001 |
| Ferritin [ng/ml] | – | 578 (287–1200) | – |
| Calcium [mg/dl] | – | 8.46 ±1.54 | – |
| Phosphorus [mg/dl] | – | 5.00 ±1.55 | – |
| Parathormone [pg/ml] | – | 589 (284–1078) | – |
| CRP [mg/dl]*** | 0.33 (0.22–0.53) | 0.85 (0.44–1.29) | < 0.001 |
| NLR*** | 1.85 (1.57–2.31) | 3.07 (1.78–3.82) | 0.001 |
| EAT [mm]*** | 5.5 (4–7) | 8 (5–10) | 0.001 |
| LVM [g]*** | 85 (79–94) | 208 (193–233) | < 0.001 |
| LVMI [g/m2]*** | 48 (44–54) | 119 (111–139) | < 0.001 |
| EF (%)*** | 67 (65–67) | 64 (60–66) | < 0.001 |
*
χ2
**
independent sample t test (mean ± SD)
***
Mann-Whitney U test [median (IQR)]
BMI – body mass index, SBP – systolic blood pressure, DBP – diastolic blood pressure, CRP – C-reactive protein, NLR – neutrophil-to-lymphocyte ratio, EAT – epicardial adipose tissue, LVM – left ventricular mass, LVMI – left ventricular mass index, EF – ejection fraction.