Table II.
Distribution of genotypes and alleles of SCN1A IVS5-91 rs3812718 G>A polymorphism in relation to type of epilepsy
| Variable | Generalized epilepsy* | Partial epilepsy* | P-value | aOR (95% CI) | P-value |
|---|---|---|---|---|---|
| Genotype: | 0.135 | ||||
| G/G | 6 (9.2) | 27 (20.0) | Reference | ||
| A/G | 55 (84.6) | 98 (72.6) | 2.60 (0.98–6.91) | 0.055 | |
| A/A | 4 (6.2) | 10 (7.4) | 2.97 (0.64–13.80) | 0.165 | |
| Genotype: | 0.055 | ||||
| G/G | 6 (9.2) | 27 (20.0) | Reference | ||
| A/G or A/A | 59 (90.8) | 108 (80.0) | 2.62 (1.00–6.94) | 0.050 | |
| Allele: | 0.371 | ||||
| G | 67 (51.5) | 152 (56.3) | Reference | ||
| A | 63 (48.5) | 118 (43.7) | 1.31 (0.84–2.04) | 0.231 |
*
Data are expressed as number of patients and percentage (%); aOR – adjusted odds ratio for gender and age. Marginal statistical significance of SCN1A IVS5-91 rs3812718 G>A polymorphism and generalized epilepsy in A-containing genotypes (p = 0.050). Significant differences are bolded.