Table IV.
Distribution of genotypes and alleles of SCN1A IVS5-91 rs3812718 G>A polymorphism in relation to AED responsiveness
| Variable | Drug responder* | Drug-resistant* | P-value | aOR (95% CI) | P-value |
|---|---|---|---|---|---|
| Genotype: | 0.463 | ||||
| G/G | 19 (14.6) | 14 (20.0) | Reference | ||
| A/G | 103 (79.2) | 50 (71.4) | 0.93 (0.41–2.16) | 0.874 | |
| A/A | 8 (6.2) | 6 (8.6) | 1.45 (0.35–6.07) | 0.608 | |
| Genotype: | 0.328 | ||||
| G/G | 19 (14.6) | 14 (20.0) | Reference | ||
| A/G or A/A | 111 (85.4) | 56 (80.0) | 0.97 (0.42–2.22) | 0.946 | |
| Allele: | 0.776 | ||||
| G | 141 (54.2) | 78 (55.7) | Reference | ||
| A | 119 (45.8) | 62 (44.3) | 0.93 (0.61–1.41) | 0.730 |
*
Data are expressed as number of patients and percentage (%); aOR, adjusted odds ratio for gender and age. No significant association of SCN1A IVS5-91 rs3812718 G>A polymorphism among drug-responsive and drug-resistant patients.