Table II.
Immunohistochemical expression of Ob-R, ER and PR in the six histological types of endometrial tissues
| N | Histological diagnosis | Histopathologicala | Digital score (median ± SD)b | ||||
|---|---|---|---|---|---|---|---|
| Ob-R | ER | PR | Ob-R* | ER** | PR*** | ||
| 10 | Proliferative endometrium (PE) | (++) | (+++) | (++) | 26 ±9 | 30 ±13 | 113 ±45 |
| 20 | Secretory endometrium (SE) | (+) | (++) | (–) | 143 ±29 | 153 ±56 | 208 ±44 |
| 25 | Non-atypical hyperplasia (NAH) | (++) | (+++) | (++) | 87 ±35 | 33 ±21 | 162 ±67 |
| 19 | Atypical hyperplasia (AH) | (++) | (+++) | (+) | 98 ±34 | 42 ±22 | 161 ±59 |
| 23 | Endometrioid carcinoma (EEC) | (++) | (++) | (+) | 141 ±64 | 132 ±81 | 205 ±47 |
| 11 | Non-endometrioid carcinoma (NEC) | (+) | (+) | (–) | 177 ±68 | 214 ±37 | 224 ±41 |
| Kruskal-Wallis test | p < 0.001 | p < 0.001 | p < 0.001 | ||||
a
Histopathological score is shown as average per group;
b
Digital score is shown as the optical median value of groups ± SD. SNK test:
*
PE ≠ SE ≠ NAH =AH ≠ EEC = NEC;
**
PE ≠ SE ≠ NAH = AH ≠ EEC ≠ NEC;
***
PE ≠ SE ≠ NAH = AH ≠ EEC = NEC. Spearman correlation: Ob-R vs. ER (r = 1, p < 0.0001), Ob-R vs. PR (r = 0.943, p < 0.005). Ob-R – leptin receptor, ER – estrogen receptor, PR – progesterone receptor.