Fig. 5.

Transcriptome analysis of IAT in patients with nonalcoholic steatohepatitis (NASH) vs. Steatosis liver phenotype. A: 14,040 transcripts were initially identified (gray dots; RPM > 0, RPKM > 2); 690 were determined to be statistically differentially regulated (black dots; >1.5-fold difference, FDR < 0.10), of which 515 were significantly upregulated and 175 significantly downregulated. B: top 15 individual up- and downregulated transcripts between NASH and Steatosis. C: top 8 up- and downregulated pathways identified by IPA. D: top 2 canonical pathways identified by IPA using all up- and downregulated genes. FC, fold-change.