Table 6.

Summary of metabolic phenotypes in Ctrp12 (+/−) male and female mice fed LFD or HFD

Male		Female
HFD	LFD	HFD	LFD
Decreased serum TG (4 h food removal)	Decreased hepatic VLDL-TG secretion (poloxamer-injected mice)	Higher fasting insulin levels	No observable phenotype
Moderate improvements in lipid tolerance tests	Increased serum ketones (4 h food removal)	Moderate decrease in insulin sensitivity
Decreased hepatic VLDL-TG secretion (poloxamer-injected mice)	Upregulation of hepatic fatty acid oxidation genes	Moderate increase in hepatic glucose output (pyruvate tolerance tests)
Increased hepatic TG and cholesterol content		Increased hepatic VLDL-TG secretion (poloxamer-injected mice)

TG, triglyceride.