Table 4.
Variable | ShamA (n = 9) |
ShamS (n = 8) |
PNxA (n = 5) |
PNxS (n = 10) |
---|---|---|---|---|
Heart rate, beats/min | 335 ± 9 | 339 ± 8 | 365 ± 10 | 347 ± 8 |
LVW/BW, g/kg | 2.10 ± 0.05 | 2.20 ± 0.04 | 2.47 ± 0.04 | 2.82 ± 0.11 |
Final BW, g | 367 ± 9 | 331 ± 9 | 337 ± 10 | 325 ± 8 |
Final HW, mg | 954 ± 28 | 897 ± 23 | 998 ± 51 | 1091 ± 44 |
LVW, mg | 769 ± 23 | 727 ± 15 | 835 ± 38 | 917 ± 44 |
KW, g | 1.30 ± 0.27 | 1.03 ± 0.03 | 1.58 ± 0.12 | 1.39 ± 0.05 |
EDV, μl | 208 ± 10 | 181 ± 12 | 204 ± 12 | 165 ± 10 |
ESV, μl | 56 ± 2 | 37 ± 5 | 41 ± 5 | 18 ± 5 |
WTI | 0.39 ± 0.01 | 0.42 ± 0.03 | 0.42 ± 0.03 | 0.52 ± 0.02 |
EF, % | 73 ± 1 | 80 ± 2 | 80 ± 2 | 89 ± 2 |
VCF, s−1 | 0.76 ± 0.03 | 0.77 ± 0.03 | 0.88 ± 0.07 | 0.92 ± 0.07 |
Tei index | 0.69 ± 0.02 | 0.69 ± 0.02 | 0.75 ± 0.07 | 0.78 ± 0.04 |
Data presented in this table are: heart rate, left ventricle hypertrophy [LVW (g) to BW (kg) ratio], final body weight in g, final heart weight in mg, LVW in mg, KW in g, end-diastolic volume (ml), end-systolic volume (ml), wall thickness index, ejection fraction, velocity of circumferential shortening, and Tei index, as determined prior to sacrifice by echocardiography. Means ± SE are shown from measurements in n = 9 ShamA, 8 ShamS, 5 PNxA, and 10 PNxS animals. Data analyze with 2-way ANOVA, results of analyses found in Table 5. Abbreviations: LVW, left ventricle weight; BW, body weight; HW, heart weight; KW, kidney weight; EDV, end-diastolic volume; ESV, end-systolic volume; WTI, wall thickness index; EF, ejection fraction; VCF, velocity of circumferential shortening; Tei index, myocardial performance index; ShamA, sham operated room air exposure only (no combustible cigarette exposure); ShamS, sham-operated exposed to 5 cigarettes per day 5 days per week for 4 wk; PNxA, 5/6th partial nephrectomy room air exposure only (no combustible cigarette exposure); PNxS, 5/6th partial nephrectomy exposed to 5 cigarettes per day 5 days per week for 4 wk.