Fig. 5.

Acute CS exposure increased histone H3K56 acetylation in mouse lungs. Whole lung homogenates were used for immunoblot analysis against anti-histone H3K56 acetylation. The level of H3K56ac, but not H4K16ac, was increased in response to acute (3 days) CS exposure in mouse lungs. Both H3K56ac and H4K16ac remained unaltered in subchronic (1 mo) air- and CS-exposed mouse lungs. The band intensity was measured by densitometry, and data are shown as relative intensity to total histones H3/H4. Values are means ± SE (n = 4/group). *P < 0.05 vs. air.