Table 1.
EpiFactors database search for differentially expressed human chromatin modification enzyme qPCR array data, and their functional role as writers or erasers, mediating site-specific histone modifications in 24-h CSE-treated H292 cells
| Gene Symbol | HGNC-approved Name | Writer(s) or Eraser(s) | Type of Modification | Protein Complex | Target (Histones/DNA) |
|---|---|---|---|---|---|
| H292 cells by CSE (1%) at 24 h and control experimental condition | |||||
| ↑Aurkc | Aurora kinase C | Writer | Histone phosphorylation | H3S10, H3S28 | |
| ↑Dnmt1 | DNA (cytosine-5-)-methyltransferase 1 | Writer | DNA methylation | DNA | |
| ↑Hat1 | Histone acetyltransferase 1 | Writer | Histone acetylation | H4, H2A | |
| ↑Myst3 | K(lysine) acetyltransferase 6A | Writer | Histone acetylation | MOZ/MORF | H3, H4 |
| ↑Ncoa3 | Nuclear receptor coactivator 3 | Writer | Histone acetylation | Histone | |
| ↑Prmt5 | Protein arginine methyltransferase 5 | Writer | Histone methylation | Methylosome | H3R8, H4R3 |
| ↑Setdb2 | SET domain, bifurcated 2 | Writer | Histone methylation | H3K9 | |
| ↑Ube2b | Ubiquitin-conjugating enzyme E2B | Writer | Histone ubiquitination | H2A, H2BK121 | |
| ↑Usp16 | Ubiquitin specific peptidase 16 | Eraser | Histone deubiquitination | H2Aub | |
| ↓Csrp2bp | CSRP2 binding protein | Writer | Histone acetylation | ATAC | H4 |
| ↑Hdac2 | Histone deacetylase 2 | Eraser | Histone deacetylation | SWI/SNF_Brg1(I), SWI/S NF_Brg1(II), SWI/SNF_Br m, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, LSD-CoREST | H2AKac, H2BKac, H3Kac, H4Kac |
The genes that are significantly up- or downregulated by ≥ or ≤1.5-fold in H292 cells treated with CSE for 24 h are denoted by an up arrow (upregulated) or a down arrow (downregulated) next to the gene symbol.