Table 3.
EpiFactors database search for differentially expressed mouse chromatin modification enzymes validated by qPCR, and their functional role as writers or erasers, mediating site-specific histone modifications in acute vs. chronic CS-exposed mouse lungs
| Gene Symbol | HGNC-approved Name | Writer(s) or Eraser(s) | Type of Modification | Protein Complex | Target (Histones) |
|---|---|---|---|---|---|
| Acute CS exposure (3 days) vs. chronic CS exposure (6 mo) | |||||
| ↓DNMT1, DNMT3A, and DNMT3B | DNA (cytosine-5-)-methyltransferase 1 | Writer | DNA methylation | DNA | |
| ↓Hdac2 | Histone deacetylase 2 | Eraser | Histone deacetylation | SWI/SNF_Brg1(I), S WI/SNF_Brg1(II), SW I/SNF_Brm, NuRD, BHC, MeCP1, mSin3A, core HDAC, mSin3A-like complex, RING2-L3MBTL2, LSD-CoREST | H2AKac, H2BKac, H3Kac, H4Kac |
| ↓Hdac4 | Histone deacetylase 4 | Eraser | Histone deacetylation | H2AKac, H2BKac, H3Kac, H4Kac | |
| ↓Hat1 | Histone acetyltransferase 1 | Writer | Histone acetylation | H4, H2A | |
| ↓Prmt1 | Protein arginine methyltransferase 1 | Writer | Histone methylation | H4R3 | |
| ↓Aurkb | Aurora kinase B | Writer | Histone phosphorylation | H3S10, H3S28 | |
The genes that are significantly downregulated in chronic vs. acute CS-exposed mouse lung are denoted by a down arrow (downregulated) next to the gene symbol.