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Effects of age on the outcome of PR8 virus infection. Following intranasal inoculation with a low dose of a historic strain of mouse-adapted influenza A virus (PR8), changes in body mass (A), rectal temperature (B), and clinical disease (C) were monitored for 21 days in aged and young adult male mice (n = 10/group). *Significant difference between aged and young adult male mice are represented (P < 0.05).
