Fig. 7.

Rac1 inhibition decreases canonical Wnt signaling. A and B: lung explants from TOPGAL reporter mice cultured in absence (A) or presence (B) of Rac1 inhibitor. Lung explants from Axin2-LacZ reporter mice cultured in absence (C) or presence (D) of Rac1 inhibitor. E: quantification of Wnt inhibitors Dkk1 and Wif1 by qRT-PCR in control and treated lungs. Data are represented as means ± SE of 7 independent experiments; *P = 0.0018. F: LacZ staining of E13.5 Axin2-LacZ lung and its WT littermate.