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. 2016 Dec 20;2016:6253280. doi: 10.1155/2016/6253280

Figure 4.

Figure 4

Emodin repressed EMT by targeting ILK in A2780 and SK-OV-3 cells. (a, c) A2780 and SK-OV-3 cells were transfected with siRNA-ILK and treated with or without emodin 20 μM for 48 hours. Protein levels of ILK, p-GSK-3β, GSK-3β, β-catenin, Slug, E-cadherin, and N-cadherin were shown. (b, d) Quantitative analyses of factors in SK-OV-3 cells shown in (a) and (c). ∗ P < 0.05, ∗∗ P < 0.005, and ∗∗∗ P < 0.001. # P < 0.05, ## P < 0.005. (e) Representative transwell migration and invasion assay of A2780 and SK-OV-3 cells after transfection with siRNA of ILK with or without emodin treatment. (f) Quantification of migration and invasion capacity of SK-OV-3 cells in (e). ∗ P < 0.05, ∗∗ P < 0.005, and ∗∗∗ P < 0.001. # P < 0.05, ## P < 0.005. N.C. represents transfection of siRNA-control.