Table 1.
Summary of metabolic parameters and serum levels of urea and creatinine in the control, NA-STZ, and LD-STZ groups measured at 10, 20, and 30 weeks of the experiment. Mean values and standard deviations are shown. P versus NA-STZ: comparison of nicotinamide-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement. P versus LD-STZ: comparison of low-dose-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement. N/A: not assayed.
| Experimental groups | Control nondiabetic group | Low-dose streptozotocin-induced diabetic group | Nicotinamide-streptozotocin-induced diabetic group | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameters Mean ± standard deviation |
Week of the study | Week of the study | Week of the study | ||||||
| 10 weeks | 20 weeks | 30 weeks | 10 weeks | 20 weeks | 30 weeks | 10 weeks | 20 weeks | 30 weeks | |
| HbA1 c, % | 3.6 | 3.7 | 4.0 | 5.45 | 6.85 | 6.7 | 5.39 | 7.02 | 6.94 |
| SD | 0.29 | 0.13 | 0.26 | 0.61 | 0.21 | 0.43 | 0.34 | 0.29 | 0.27 |
| P versus NA-STZ | 0.029 | 0.01 | 0.016 | 0.97 | 0.39 | 0.46 | |||
| P versus LD-STZ | 0.028 | 0.029 | 0.028 | ||||||
|
| |||||||||
| Serum insulin level, pmol/L | 83.5 | 96.6 | 87.8 | 50.2 | 54.0 | 59.6 | 49.6 | 51.3 | 50.9 |
| SD | 6.81 | 9.18 | 6.24 | 8.13 | 10.46 | 8.93 | 7.34 | 8.72 | 8.85 |
| P versus NA-STZ | 0.028 | 0.009 | 0.015 | 0.88 | 0.76 | 0.27 | |||
| P versus LD-STZ | 0.03 | 0.027 | 0.28 | ||||||
|
| |||||||||
| HOMA-IR | 1.93 | 2.23 | 2.01 | 2.76 | 2.78 | 2.83 | 3.20 | 2.87 | 2.91 |
| SD | 0.29 | 0.14 | 0.22 | 0.92 | 0.93 | 0.87 | 0.39 | 0.22 | 0.70 |
| P versus NA-STZ | 0.028 | 0.014 | 0.031 | 0.31 | 0.99 | 0.77 | |||
| P versus LD-STZ | 0.11 | 0.48 | 0.06 | ||||||
|
| |||||||||
| Total cholesterol, mmol/L | 1.55 | 1.58 | 1.63 | 2.83 | 2.71 | 2.42 | 2.89 | 2.76 | 2.74 |
| SD | 0.35 | 0.20 | 0.27 | 0.35 | 0.19 | 0.32 | 0.25 | 0.23 | 0.21 |
| P versus NA-STZ | 0.028 | 0.014 | 0.002 | 0.88 | 0.74 | 0.11 | |||
| P versus LD-STZ | 0.028 | 0.031 | 0.008 | ||||||
|
| |||||||||
| Triglycerides, mmol/L | 0.57 | 0.56 | 0.70 | 1.13 | 1.04 | 0.86 | 1.05 | 0.90 | 0.89 |
| SD | 0.08 | 0.12 | 0.17 | 0.49 | 0.41 | 0.33 | 0.18 | 0.12 | 0.19 |
| P versus NA-STZ | 0.028 | 0.01 | 0.029 | 1.0 | 0.91 | 0.98 | |||
| P versus LD-STZ | 0.029 | 0.057 | 0.21 | ||||||
|
| |||||||||
| Serum urea, mmol/L | N/A | N/A | 6.5 | N/A | N/A | 8.7 | N/A | N/A | 8.82 |
| SD | 0.89 | 1.18 | 1.03 | ||||||
| P versus NA-STZ | 0.06 | 0.96 | |||||||
| P versus LD-STZ | 0.012 | ||||||||
|
| |||||||||
| Serum creatinine, μmol/L | 33.5 | 35.8 | 41.9 | 41.3 | 44.8 | 61.5 | 38.3 | 47.0 | 69.0 |
| SD | 3.42 | 3.61 | 4.09 | 6.24 | 6.50 | 11.62 | 2.99 | 4.0 | 4.30 |
| P versus NA-STZ | 0.14 | 0.004 | 0.002 | 0.65 | 0.80 | 0.31 | |||
| P versus LD-STZ | 0.11 | 0.038 | 0.008 | ||||||