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Increased anxiety and impaired fear-related learning in OGT cKO mice. (A) In an open field test, OGT cKO mice showed a reduction in the time spent in the middle quadrant of the box and in the total distance traveled. (B) Deficits in cued fear conditioning were observed at 2 mo in OGT cKO mice, and deficits in both cued and contextual learning and memory were observed at 4 mo. n = 12 per group. *P < 0.05, **P < 0.005.
