Fig. S9.

Relationship between binding affinity and inhibition potency. The 14 inhibitory clones isolated in this study form four clusters: group 1 (seven of 14 clones), high inhibition potency and high binding affinity; group 2 (two of 14 clones), high binding affinity and low inhibition potency; group 3 (three of 14 clones), moderate binding affinity and moderate inhibition potency; and group 4 (two of 14 clones), low binding affinity and moderate inhibition potency. Clones in group 1 can serve as leads for further characterizations. Clones in group 2 presumably have their paratopes partially contribute to inhibition. Clones in groups 3 and 4 probably bind to inhibitory epitopes with suboptimal strengths and are therefore suitable for further affinity maturation.