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. 2016 Dec 13;113(52):15018–15023. doi: 10.1073/pnas.1611861114

Fig. 4.

Fig. 4.

(A and B) E1 component of the branched-chain 2-oxo acid dehydrogenase in T. thermophilus [A, PDB ID code 1UMB (61)] and the human mitochondrial pyruvate dehydrogenase E1 component of the pyruvate dehydrogenase complex [B, PDB ID code 3EXI (40)]. In the zoomed inset coevolving pairs of residues are shown as sticks and connected by dashed lines (yellow if they are in contact, magenta otherwise). Ten contacts out of 13 coevolving pairs are detected at the T. thermophilus interface (A). Eleven out of these 13 pairs can be mapped to the human complex where they are all in contact (B). (C and D) Protein transportation channels across bacterial plasma membrane SecYE in T. thermophilus X-ray structure of SecY (in dark red) in complex with SecE (in dark blue) [C, PDB ID code 2ZJS (62)]. Eukaryotic endoplasmic reticulum Sec61 in C. lupus EM structure of Sec61 complex with its α subunit in dark red and γ subunit in dark blue [D, PDB ID code 4CG7 (63)]. The three coevolving pairs (drawn as sticks) are in contact in T. thermophilus and two of them are conserved in the C. lupus structure.