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. 2016 Dec 12;113(52):E8387–E8395. doi: 10.1073/pnas.1612719113

Fig. 6.

Fig. 6.

Model. Actin filaments with parallel polarity are cross-linked by the motor domains of single myosin-IXa molecules adopting three interchangeable conformations (I, II, and III) (Inset) that can be obtained at binding sites with free-energy minima. IXa-MD does not remain bound to single-actin filaments, and the precise 36-nm spacing is obtained due to the constraints set by the length and flexibility of loop 2 and the distances between actin filaments specified by their geometries.