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. 2016 Dec 8;113(52):E8443–E8452. doi: 10.1073/pnas.1610531113

Fig. S2.

Fig. S2.

CRMP2 modification relocalizes NaV1.7 to recycling endosomes. (A) Representative confocal images of NaV1.7 colocalization with Rab11 in CRMP2, CRMP2-K374A, and CRMP2-S522A expressing DRG neurons (n = 8). (B) Quantitative analysis of NaV1.7 colocalization with Rab11, a specific marker or recycling endosomes. (C) Quantitative analysis of TTX-S and TTX-R DRG sodium currents in cells expressing CRMP2-K374A/S522A treated with 10 µM Lactacystin for 24 h. Lactacystin did not alter any current properties of CRMP2-K374A/S522A–expressing cells. Data show means ± SEM (*P < 0.05, Kruskal–Wallis test with Dunnett’s post hoc comparisons in B and t test in C).