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TevCas9 can bias the proportion of in-frame to out-of-frame indels. Illumina read data for the NQO2 target site is plotted as the proportion of reads that are in frame (green) and out of frame (purple) for (A) TevCas9 (triangles) and (B) Cas9 (open circles). (C) Fraction of reads that are in frame or out of frame for TevCas9 and Cas9.
