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. 2016 Dec 12;113(52):15126–15131. doi: 10.1073/pnas.1611023114

Fig. S4.

Fig. S4.

CCR2 inhibition and CCR2KO BMT reduce leukocyte infiltration into the heart following MI. (A) Representative CD68, tryptase, and MPO staining for the infarct zone of hearts from WT C57BL/6 mice that underwent MI surgery followed by administration (i.p.) of 2 mg⋅kg−1⋅d−1 of a CCR2 antagonist or vehicle for 4 d or WT C57BL/6 mice receiving WT, β2ARKO, or CCR2KO BMT animals that underwent MI surgery. Arrowheads indicate positive staining. Insets show higher magnification at 250×. (B–D) Quantification of CD68 (B), tryptase (C), and MPO (D) staining for the infarct zone of 4-d post-MI hearts from Veh- and CCR2 antagonist-treated mice or WT, β2ARKO, and CCR2KO BMT animals. n = 4–8; t test or one-way ANOVA, *P < 0.05 vs. WT BMT or Veh, ‡P < 0.001 vs. Veh BMT. Data are expressed as mean ± SEM.