Fig. 2.

Alterations in GALR3 mRNA and DNA methylation in the dorsolateral prefrontal cortex (BA 8/9) of male and female DS subjects. (A and E) Gene-expression levels of GALR3 in the dorsolateral prefrontal cortex of male (A) and female (E) controls and DS subjects. (B–D and F–H) Percentage of DNA methylation levels at individual CpG sites of the GALR3 gene in male (B–D) and female (F–H) controls and DS subjects. All data are presented as mean ± SEM; n = 10 per group. Significant differences between DS subjects and controls are indicated: **P < 0.01. CON, controls; DS, depressed suicide.