Fig. S3.

Alterations in GALR1 and GALR2 gene expression and DNA methylation in the dorsal raphe nucleus of male and female DS subjects. Gene-expression levels of GALR1 and GALR2 in the dorsal raphe nucleus of male (A and E) and female (C and G) controls and DS subjects. Percent DNA methylation levels at individual CpG sites of the GALR1 and GALR2 gene in male (B and F) and female (D and H) control and DS subjects. All data are presented as mean ± SEM, n = 10 per group. Significant differences between DS subjects and controls are indicated: *P < 0.05. CON, controls; DS, depressed suicide.