Fig. S5.

Alterations in GAL and GALR1-3 gene expression and DNA methylation in the medullary raphe nuclei of male and female DS subjects. Gene expression levels of GAL and GALR1-3 in the medullary raphe nuclei of male (A, E, I, and M) and female (C, G, K, and O) controls and DS subjects. Percent DNA methylation levels at individual CpG sites of the GAL and GALR1-3 genes in male (B, F, J, and N) and female (D, H, L, and P) control and DS subjects. All data are presented as mean ± SEM; n = 10 per group. Significant differences between DS subjects and controls are indicated: *P < 0.05, **P < 0.01. CON, controls; DS, depressed suicide.