Table 3.
Overview of mRNA and DNA methylation changes
| GAL | GALR1 | GALR2 | GALR3 | ||||||||||||||||
| gDNA methylation | gDNA methylation | gDNA methylation | gDNA methylation | ||||||||||||||||
| Regions | Sex | mRNA | CpG1 | CpG2 | CpG3 | mRNA | CpG1 | CpG2 | CpG3 | CpG4 | mRNA | CpG1 | CpG2 | CpG3 | CpG4 | mRNA | CpG1 | CpG2 | CpG3 |
| DLPFC | M | ↓↓ | ↑ | ↑↑ | ↑↑ | ↑ | — | — | — | — | — | — | — | — | — | ↓↓ | — | — | — |
| F | ↑ | ↑ | ↓ | — | ↑ | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| ACC | M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| F | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | |
| DRN | M | ↑↑ | — | ↓ | ↑ | — | — | — | — | — | — | — | — | — | ↑ | — | — | — | |
| F | ↑↑ | — | — | — | — | — | — | — | — | — | — | — | — | — | ↑↑ | ↓↓ | ↓↓ | — | |
| LC | M | ↑↑ | ↓↓ | ↓ | — | — | — | — | — | — | — | — | — | — | — | ↑ | ↓ | — | |
| F | ↑↑ | ↓ | ↓↓ | — | — | — | — | — | — | — | — | — | — | — | ↑↑ | ↓ | ↓↓ | — | |
| MRN | M | ↑ | — | — | — | ↑ | — | — | — | — | ↓↓ | — | — | — | — | ↑ | — | — | — |
| F | ↑ | — | — | — | — | — | — | — | — | — | — | — | — | ↑ | — | — | — | ||
The arrows represent statistical significance; upward arrows signify increased in gene expression and methylation status, and downward arrows signify decreased gene expression and methylation status. A single arrow represents P < 0.05, and two arrows represent P < 0.01. ACC, anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; DRN, dorsal raphe nucleus; LC, locus coeruleus; MRN, medullary raphe nucleus.