Table 3. Association between combined risk genotypes of MDM2rs2279744 and MDM2rs937283 and recurrence risk in 1008 patients with SCCOP.
| Combined MDM2 genotypes | No. of recurrences/no. of patients | 5-year recurrence rate, % | Log-rank P value | aHR* (95% CI) |
|---|---|---|---|---|
| Low-risk group† | 23/379 | 6 | <0.0001 | 1.0 |
| Medium-risk group | 83/490 | 17 | 2.7 (1.7–4.2) | |
| High-risk group | 75/139 | 57 | 10.9 (6.8–17.4) | |
| Trend test | <0.001 | |||
| Combined MDM2genotypes | No. of risk genotypes (no. of recurrences/no. of patients) | Genotypes of MDM2 polymorphisms | aHR* (95% CI) | |
| rs2279744 | rs937283 | |||
| 1 | Low (9/205) | GG† | GG† | 1.0 |
| 2 | Low (5/71) | GG | AG | 1.9 (0.3–3.2) |
| 3 | Medium (19/192) | GG | AA | 3.4 (1.1–5.8) |
| 4 | Low (4/67) | GT | GG | 1.4 (0.4–4.2) |
| 5 | Low (5/36) | GT | AG | 2.6 (0.6–5.3) |
| 6 | Medium (28/99) | GT | AA | 11.2 (6.5–20.1) |
| 7 | Medium (4/67) | TT | GG | 1.9 (1.0–3.7) |
| 8 | Medium (32/132) | TT | AG | 7.1 (3.7–13.6) |
| 9 | High (75/139) | TT | AA | 26.8 (10.3–48.7) |
aHR, adjusted hazard ratio; CI, confidence interval.
*Adjusted for age, sex, ethnicity, smoking status, alcohol use status, disease stage, comorbidity, and treatment.
†Reference group.