Table 3.

Independent Prognostic Factors for Recurrence in Multivariate Analysis According to Age

Whole patient population	RR	[95% CI]	p
Overall RFS
Age	2.5	[1.2–5.1]	0.01
Extra-thyroid extension	2.6	[1–6.5]	0.05
No of metastatic nodes (>3)	3.2	[1.1–8.8]	0.03
Neck RFS
No of metastatic nodes (>3)	4.3	[1.2–15.2]	0.03
Distant RFS
Age	7.6	[2.0–28.8]	0.003
Patients <45 years old
Overall RFS
No of metastatic nodes (>3)	8.2	[0.9–72.2]	0.05
Neck RFS
None found
Distant RFS
NA
Patients ≥45 years old
Overall RFS
None found
Neck RFS
No of metastatic nodes (>5)	9.6	[1.1–83.3]	0.04
Distant RFS
Margins	4.7	[1–21.6]	0.04

RR, risk ratio; CI, confidence interval; NA, not applicable (multivariate was not possible in view of the low number of events).