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. 2017 Jan 3;7:39501. doi: 10.1038/srep39501

Figure 6. Plumericin, PHA-408, and NAC prevent induction of SASP in HUVECs.

Figure 6

(a) Surface expression of E-selectin quantified by cell ELISA at day nine and (b) mRNA level of IGFBP-5 quantified by qPCR of HUVECs grown in the presence of TNFα (10 ng/ml) ± inhibitors in comparison to control HUVECs ± inhibitors. (c) IL-6 levels and (d) IL-8 levels in HUVECs grown in the presence of TNFα (10 ng/ml) ± inhibitors in comparison to control HUVECs. Values are presented as mean ± SD of technical triplicates (a,b) or duplicates (c,d). (*p < 0.05, **p < 0.01, ***p < 0.001). The results shown are representative of three independent experiments. C: control, PL: plumericin, PHA: PHA-408, NAC: N-acetyl cysteine.