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. 2017 Jan 3;7:39662. doi: 10.1038/srep39662

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Effect of vehicle (●) or 0.3 μg (), 1 μg () or 5 μg () JNJ63955918 on formalin-induced flinching. The vertical dotted line separates phase I (0–10 min) from phase II (11–60 min). (B) Comparison of JNJ63955918 (red circles), ziconotide (open triangles) and morphine (closed triangles) in the formalin model. (C) Effect of intrathecal vehicle () or 0.3 μg (), 1 μg (), 5 μg () or 7.5 μg () JNJ63955918 on thermally-induced tail flick. Latencies were significantly elevated between 15 and 120 min following 1 μg JNJ63955918 and between 15 and 360 min after 5 μg and 7.5 μg JNJ63955918 (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (D) Effect of intrathecal vehicle () or 0.3 μg (), 1 μg (), 5 μg () or 7.5 μg () JNJ63955918 on escape latency in the hotplate assay. Latencies were significantly elevated between 15 and 120 min following 1 μg JNJ63955918 and between 15 and 360 min after 5 μg and 7.5 μg JNJ63955918 (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (E) Dose-response curves for JNJ63955918 in the rat tail flick and hotplate assays. Data are represented as mean ± s.e.m, n = 6–10 animals/group.

Inline graphic — (A) Effect of vehicle (●) or 0.3 μg (), 1 μg () or 5 μg () JNJ63955918 on formalin-induced flinching. The vertical dotted line separates phase I (0–10 min) from phase II (11–60 min). (B) Comparison of JNJ63955918 (red circles), ziconotide (open triangles) and morphine (closed triangles) in the formalin model. (C) Effect of intrathecal vehicle () or 0.3 μg (), 1 μg (), 5 μg () or 7.5 μg () JNJ63955918 on thermally-induced tail flick. Latencies were significantly elevated between 15 and 120 min following 1 μg JNJ63955918 and between 15 and 360 min after 5 μg and 7.5 μg JNJ63955918 (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (D) Effect of intrathecal vehicle () or 0.3 μg (), 1 μg (), 5 μg () or 7.5 μg () JNJ63955918 on escape latency in the hotplate assay. Latencies were significantly elevated between 15 and 120 min following 1 μg JNJ63955918 and between 15 and 360 min after 5 μg and 7.5 μg JNJ63955918 (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (E) Dose-response curves for JNJ63955918 in the rat tail flick and hotplate assays. Data are represented as mean ± s.e.m, n = 6–10 animals/group.