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. 2017 Jan 3;7:39662. doi: 10.1038/srep39662

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Copyright © 2017, The Author(s)

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Effect of 14 d intrathecal infusion of vehicle(○) or 0.5 μg/h JNJ63955918 (●) in the rat tail flick (A) and hotplate (B) models. Latencies were significantly elevated between day 3 and day 14 in the tail flick assay and between day 3 and day 20 in the hotplate assay (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (C) Effect of intrathecal vehicle (), 1 μg JNJ63955918 () or 10 μg morphine () on formalin-induced flinching in morphine-tolerant rats. (D) Average effects of intrathecal vehicle, 1 μg JNJ63955918 or 10 μg morphine on phase I and phase II responses in the formalin model (*denotes P < 0.05, 1-way ANOVA). Phase I = 0~10 min and Phase II = 11~60 min. Data are represented as mean ± s.e.m, n = 5-8 rats/group.

Inline graphic — Effect of 14 d intrathecal infusion of vehicle(○) or 0.5 μg/h JNJ63955918 (●) in the rat tail flick (A) and hotplate (B) models. Latencies were significantly elevated between day 3 and day 14 in the tail flick assay and between day 3 and day 20 in the hotplate assay (2-way ANOVA with Bonferroni multiple comparisons vs baseline for each group). (C) Effect of intrathecal vehicle (), 1 μg JNJ63955918 () or 10 μg morphine () on formalin-induced flinching in morphine-tolerant rats. (D) Average effects of intrathecal vehicle, 1 μg JNJ63955918 or 10 μg morphine on phase I and phase II responses in the formalin model (*denotes P < 0.05, 1-way ANOVA). Phase I = 0~10 min and Phase II = 11~60 min. Data are represented as mean ± s.e.m, n = 5-8 rats/group.