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. 2017 Jan 3;7:39994. doi: 10.1038/srep39994

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Copyright © 2017, The Author(s)

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(a) Irrespective of ADAR2 expression (arrow), all AHCs in an AR2res mouse expressed Nup62 protein in the perinuclear region. TO-PRO-3 is a cellular staining marker. Scale bars, 20 μm. (b) The numbers of AHCs that were notably immunoreactive for Nup62 and TDP-43 in the AR2, AR2res and wild-type (WT) mice at different ages. The mean number of AHCs ± s.e.m. in a single anterior horn is indicated (n = 4–5, **P < 0.005 compared to the levels in wild-type or AR2 mice, Mann-Whitney U-test). +: positive immunoreactivity; −: negative immunoreactivity.