Table 2.
Groups Immunization administration |
No. of surviving mice/total No. of micea
|
|
---|---|---|
Intranasal route | Intraperitoneal route | |
χ3761 (wild-type) | 4/5 (80%) | 5/5 (100%) |
χ12253 (ΔwaaC12) | 4/5 (80%) | 5/5 (100%) |
χ12252 (ΔwaaF15) | 2/5 (40%) | 3/5 (60%) |
χ11308 (ΔwaaG42) | 0/5 (0%) | 2/5 (40%) |
χ9945 (ΔrfaH49) | 3/5 (60%) | 5/5 (100%) |
χ11309 (ΔwaaI43) | 0/5 (0%) | 2/5 (40%) |
χ11310 (ΔwaaJ44) | 3/5 (60%) | 3/5 (60%) |
χ11312 (ΔwaaL46) | 1/5 (20%) | 3/5 (60%) |
χ11311 (ΔrfbP45) | 4/5 (80%) | 4/5 (80%) |
χ9944 (Δwzy-48) | 1/5 (20%) | 3/5 (60%) |
PBS group | 0/5 (0%) | 0/8 (0%) |
All vaccine groups except groups of intranasal immunization of χ11309 (ΔwaaI43) and χ11308 (ΔwaaG42) were significantly different from the PBS-vaccinated group (P < 0.01). There was no significant difference in protection among the other groups.