Table 2.
Immunization with truncated LPS OMVs protected mice against oral challenge with S. Typhimurium strain S100.
| Groups Immunization administration |
No. of surviving mice/total No. of micea
|
|
|---|---|---|
| Intranasal route | Intraperitoneal route | |
| χ3761 (wild-type) | 4/5 (80%) | 5/5 (100%) |
| χ12253 (ΔwaaC12) | 4/5 (80%) | 5/5 (100%) |
| χ12252 (ΔwaaF15) | 2/5 (40%) | 3/5 (60%) |
| χ11308 (ΔwaaG42) | 0/5 (0%) | 2/5 (40%) |
| χ9945 (ΔrfaH49) | 3/5 (60%) | 5/5 (100%) |
| χ11309 (ΔwaaI43) | 0/5 (0%) | 2/5 (40%) |
| χ11310 (ΔwaaJ44) | 3/5 (60%) | 3/5 (60%) |
| χ11312 (ΔwaaL46) | 1/5 (20%) | 3/5 (60%) |
| χ11311 (ΔrfbP45) | 4/5 (80%) | 4/5 (80%) |
| χ9944 (Δwzy-48) | 1/5 (20%) | 3/5 (60%) |
| PBS group | 0/5 (0%) | 0/8 (0%) |
a
All vaccine groups except groups of intranasal immunization of χ11309 (ΔwaaI43) and χ11308 (ΔwaaG42) were significantly different from the PBS-vaccinated group (P < 0.01). There was no significant difference in protection among the other groups.