Table 1.

Binding parameters for oxygen and carbon monoxide of hemoglobin and neuroglobin

Protein	O2 kon (M−1s−1)	O2 koff (s−1)	O2 KA (M−1)	CO kon (M−1s−1)	CO koff (s−1)	CO KA (M−1)	M (KACO/KAO2)	kautox (h−1)
Hb R a	5.0 × 107	1.5 × 101	3.3 × 106	6.0 × 106	1.0 × 10−2	6.0 × 108	1.8 × 102	ND
Hb T a	4.5 × 106	1.9 × 103	2.4 × 103	8.3 × 104	9.0 × 10−2	9.2 × 105	3.9 × 102	ND
hNgb b	2.5 × 108	0.8	3.1 × 108	6.5 × 107	1.4 × 10−2	4.6 × 108	14	5.4
hNgb H64Q-CCC c	7.2 × 108	18	3.9 × 107	1.6 × 108	4.2 × 10−4	3.8 x1011	9.7 × 103	0.83

^a(22);

^b(14);

^cThis work.

ND, not determined