. Author manuscript; available in PMC: 2017 Jan 3.

Published in final edited form as: J Pediatr Oncol Nurs. 2014 May 5;31(4):191–199. doi: 10.1177/1043454214532024

Table 3. Continuous Bladder Irrigation with Hydration Evidence.

First Author, Year Study Design	Subjects	Findings	GRADE quality level
Hajibabaie, 2008 Non-randomized trial with historical controls	80 adult SCT patients	No HC prevalence difference between IV hydration versus IV hydration with CBI (p=0.11)	Moderate
Vose, 1993 RCT	200 adult SCT patients	No HC prevalence difference between IV hydration plus mesna versus IV hydration plus CBI but more bladder spasm, discomfort, and urinary tract infections in CBI group	High
Meisenberg, 1994 Retrospective	303 adult SCT patients	CBI plus IV hydration at 200ml/m2/hour is effective in preventing HC	Moderate

Abbreviations: RCT = randomized control trial; SCT = stem cell transplant; IV = intravenous; CTX = Cytoxan; HC = hemorrhagic cystitis; CBI = continuous bladder irrigation