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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Bioessays. 2016 Oct 24;38(12):1234–1245. doi: 10.1002/bies.201600154

Figure 2.

Figure 2

Frizzled (Fz) planar cell polarity core components in Drosophila wings and mouse trachea. A: Drosophila wing blades are formed by two layers of polarized epithelial cells with the apical domain facing the wing surface. Following the proximal-distal axis, Fz-PCP core components are asymmetrically localized to a distal complex including Fz-Dsh-Fmi-Dgo and a proximal complex formed by Vang-Pk-Fmi. This pattern is reproduced in every single cell throughout the wing blade. B: In mouse tracheal epithelial cells, the apical domains face the lumen. In an analogous manner to Drosophila wing epithelial cells, the Fz-PCP core components are segregated in proximal (lung side) and distal (mouth side) complexes, containing the equivalent orthologues as in Drosophila. In addition to the several isoforms for most of the Fz-PCP core components, in mouse tracheal epithelial cells Diversin (the vertebrate Dgo homolog) and Dvl2 are detected near the basal bodies in these multiciliated cells.