Table 2.
Effect of daily oral administration of bisphenol A (50 mg/kg body weight) for 8 weeks on serum liver function biomarkers and cytokines as well as hepatic oxidative stress markers in male rats
| Groups | Parameters | |||||||
|---|---|---|---|---|---|---|---|---|
| ALT (U/l) | AST (U/l) | IL‐1β (pg/ml) | IL‐10 (pg/ml) | IL‐1β/IL‐10 | MDA (nmol/g tissue) | GSH (mmol/g tissue) | CAT (U/g tissue) | |
| Normal group | 20.09 ± 1.07 | 41.3 ± 3.09 | 96.8 ± 6.03 | 95 ± 4.43 | 1.03 ± 0.11 | 129.7 ± 3.79 | 2.68 ± 0.18 | 5.72 ± 0.11 |
| Control group | 16.68 ± 1.72* | 34.17 ± 4.4* | 78.88 ± 2.61* | 109 ± 6.29* | 0.73 ± 0.06 | 81.6 ± 2.67* | 3.47 ± 0.29* | 6.09 ± 0.07* |
| BPA group | 57.43 ± 1.84$ | 97.04 ± 4.98$ | 238.1 ± 19.33$ | 15.18 ± 1.82$ | 16.01 ± 3.34$ | 307 ± 10.09$ | 0.71 ± 0.04$ | 1.72 ± 0.04$ |
Values were expressed as mean ± SD (n = 6/group). *Significantly different from normal group at P < 0.05, $significantly different from control group at P < 0.001 using anova followed by Tukey–Kramer as a post hoc test. BPA, bisphenol A; ALT, alanine aminotransferase; AST, aspartate aminotransferase; IL‐1β, interleukin‐1beta; IL‐10, interleukin‐10; MDA, malondialdehyde; GSH, reduced glutathione; CAT, catalase.