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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Aug 3;1863(11):2624–2636. doi: 10.1016/j.bbamcr.2016.07.008

Figure 8. Proposed model of ouabain action in the proximal tubule.

Figure 8

(1) Endogenous ouabain binds to and inhibits high-affinity NKA in the basolateral membrane of the proximal tubule, (2) resulting in an increase in intracellular sodium, ACE, and Ang II. (3) Ang II binds AT1 receptors in the basolateral membrane in an autocrine manner. (4) AT1R activation stimulates its association with NKA and (5) the activation of EGFR. (6) EGFR signaling stimulates the translocation of intracellular NKA to the plasma membrane, ultimately resulting in increased sodium reabsorption in the kidney and higher systemic blood pressure.