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. Author manuscript; available in PMC: 2017 May 21.
Published in final edited form as: Nat Genet. 2016 Nov 21;49(1):10–16. doi: 10.1038/ng.3726

Figure 2. Genes with higher frequencies of somatic loss-of-function (LOF) alterations in male cancers.

Figure 2

Permutation testing for genes on chrX across all cancer datasets is shown. The log2 M:F ratio of events is plotted for each gene against the significance (P) value. The size and color of each circle represent the number of (a) LOF mutations, or (b) LOF mutation/CN loss events in that gene. Genes with significantly higher (FDR<0.1) frequencies of mutation in male cancers are identified. Disease-specific permutation testing of LOF mutations in (c) lower-grade glioma and (d) clear cell kidney cancer is shown.