. Author manuscript; available in PMC: 2017 Jan 3.

Published in final edited form as: ACS Appl Mater Interfaces. 2016 Dec 2;8(49):33412–33422. doi: 10.1021/acsami.6b08153

Table 2.

Optimized PEGylated-PLGA NPs Used in the Cell Culture Studies

					gemcitabine/antisense-miRNA-21
S no.	PEGylated-PLGA-NPs	mean Size (nm)^a	PDI^a	ζ potential	EE (%)^a	loading (%)	antisense-miRNA molecules/NP
1	control NPs	198.4 ± 18.4	0.187	−15.7 ± 3.1
2	gemcitabine	201.8 ± 15.1	0.155	−14.7 ± 2.6	42 ± 6.2/−	2.1/−
3	antisense-miRNA-21	205.1 ± 18.1	0.189	−22.6 ± 2.9	−/64.8 ± 9.6	−/0.45	1680 ± 185
4	gemcitabine and antisense-miRNA-21	212.6 ± 16.3	0.148	−18.8 ± 2.4	40 ± 6.3/62.7 ± 8.6	2.0/0.43	1630 ± 176

Note: average from three experiments.