Table 3.
Hep3B |
HepG2 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
apoptotic cells (%) |
live cells (%) |
G0/G1 phase (%) |
S phase (%) |
G2/M phase (%) |
apoptotic cells (%) |
live cells (%) |
G0/G1 phase (%) |
S phase (%) |
G2/M phase (%) |
|
control cells | 1.69 | 98.2 | 41.7 | 29.9 | 27.4 | 1.74 | 98.2 | 39.6 | 27.9 | 34.6 |
control NPs | 1.61 | 98.4 | 44.4 | 27.6 | 27.9 | 1.47 | 98.5 | 41.4 | 27.8 | 30.8 |
free GEM | 9.43 | 90.4 | 86.7 | 3.3 | 9.85 | 12.2 | 87.7 | 88.6 | 4.54 | 6.78 |
GEM NPs | 13.7 | 86.2 | 88.6 | 4.42 | 6.57 | 14.8 | 85.1 | 90.4 | 3.47 | 6.30 |
antisense-miRNA-21 NPs | 0.98 | 99.0 | 50.2 | 18.1 | 32.0 | 2.30 | 97.6 | 52.8 | 18.0 | 29.1 |
antisense-miRNA-21 + GEM NPs | 9.87 | 90.1 | 90.0 | 2.69 | 7.25 | 14.0 | 85.9 | 89.4 | 3.70 | 6.86 |