Table 1.
Subject characteristics (mean±SD)
| All subjects n=16 | IOP n=9 | Controls n=7 | % difference IOP vs controls |
p: IOP vs controls |
|
|---|---|---|---|---|---|
| Age (years) | 35.9±7 | 34.8±6.6 | 37.2±7.9 | 0.5 | |
| BMI (kg/m2) | 23.1 ±3.1 | 22.4±3.6 | 24.0±2.4 | 0.3 | |
| Body fat by DXA (%) | |||||
| Whole body fat | 32.7±8.8 | 31.9±9.7 | 33.7±8.2 | 0.7 | |
| Trunk fat | 28.7±9.6 | 27.9±10.5 | 29.8±9.1 | 0.7 | |
| BMD Z-score | |||||
| Lumbar spine | −0.86±1.62 | −2.04±0.74 | 0.66±1.05 | <0.0001 | |
| Total hip | −0.48±1.21 | −1.24±1.01 | 0.49±0.58 | 0.013 | |
| Femoral neck | −0.84±1.22 | −1.61±0.96 | 0.14±0.69 | 0.001 | |
| Distal radius | 033±0.99 | −0.00±0.96 | 0.76±0.93 | 0.1 | |
| Histomorphometry | |||||
| Trabecular BV/TV (%) | 20.30±4.34 | 19.06±3.23 | 21.90±5.28 | 0.2 | |
| Cancellous BFR (mm2/mm/year) | 0.013±0.009 | 0.012±0.009 | 0.014±0.010 | 0.7 | |
| 1H-MRS fat fraction | |||||
| Spine (L3; %) | 35.0±9.2 | 36.4±10.3 | 33.2±8.0 | 10 % higher | 0.5 |
| Femur (%) | 66.3±13.2 | 71.0±14.8 | 60.2±8.3 | 18 % higher | 0.1 |
| Adipocyte measures on biopsies | |||||
| Ad.V/Ma.V (%) | 27.2±7.8 | 30.7±6.8 | 22.5±6.8 | 36 % higher | 0.03 |
| Ad.Ar (mm2) | 0.24±0.08 | 0.28±0.07 | 0.20±0.07 | 40 % higher | 0.02 |
| Ad.Pm (mm) | 25.3±8.3 | 28.3±8.8 | 21.5±6.0 | 32 % higher | 0.1 |
| Ad.N (n/mm2 tissue) | 187±58 | 211 ±61 | 156±37 | 35 % higher | 0.06 |
| Ad.D.(n/mm2 marrow) | 209±56 | 230±60 | 182±38 | 26 % higher | 0.09 |
BV/TV bone volume/total volume, BFR bone formation rate/bone surface, Ad.Ar Adipocyte area, Ad.Pm total adipocyte perimeter, Ad.N adipocyte number per square millimeter tissue area, Ad.V/Ma.V percent adipocyte volume per marrow volume, Ad.D adipocyte density (adipocyte number per square mm marrow tissue area)