Table 1.

Serum levels of total protein, PLA2 and histamine levels in control group, sensitized guinea pigs (s), s treated with three concentrations of carvacrol (S+C1, S+C2, S+C3) and dexamethasone (S+D), (n= 6).

Mediator	Control	S	S+D	S +C1	S+C2	S+C3
Total protein	5.35±0.25	9.1±0.32	7.36±1.81	14.80±2.66	4.90±1.18	3.94±0.51
PLA2	7.49±0.54	12.12±1.34	7.68±0.75	22.05±3.07	7.48±0.09	7.39±0.04
Histamine	7.73±1.15	32.92±1.62	28.45±2.01	27.05±1.81	17.34±2.3	1.84±0.25***

Values are presented as mean±SEM. Three concentrations of carvacrol were 40 (S+C1), 80 (S+C2) and 160 µg/ml (S+C3) and dexamethasone was used at the concentration of 50 μg/ml. Statistical significance for the difference between the data of S+C3 and S+C1 vs S+C1:

p<0.01,

p<0.001. Statistical significance for the difference between the data of S+C3 vs S+C2:

^***p<0.001. The statistical comparisons were made using ANOVA with Tukey- Kramer multiple post test.