Table 1.
Response rates according to histology
| Pathway | Drug | Target | Response rate in different histologies (%) | |||||
|---|---|---|---|---|---|---|---|---|
| DLBCL | FL | MCL | SLL/CLL | T-cell | HL | |||
| PI3K/ AKT/m TOR |
Everolimus Temsirolimus CAL-101 |
mTOR mTOR PI3K |
30 36 0 |
50 56 55 |
32 38 67 |
18 10 30 |
63 – – |
53 – – |
| B-cell receptor |
Fostamatinib PC132765 |
Syk Btk |
22 17 |
10 23 |
11 69 |
55 67 |
0 – |
– – |
Abbreviations: CLL, chronic lymphocytic leukaemia; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; HL, Hodgkin lymphoma; MCL, mantle-cell lymphoma; SLL, small lymphocytic lymphoma.