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Predicting response rates for therapies based on pathway signatures
| Histology | n | Incidence of activated PI3K pathway gene signature (%) |
Predicted response rate to PI3K and mTOR pathway inhibitors (%) |
|
|---|---|---|---|---|
| Absent | Present | |||
| DLBCL | 73 | 38 | 62 | 30–36 |
| FL | 184 | 54 | 46 | 50–56 |
| HL | 130 | 52 | 48 | 53 |
| MCL | 15 | 73 | 27 | 32–67 |
| PTCL | 50 | 44 | 56 | 63 |
Abbreviations: DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; HL, Hodgkin lymphoma; MCL, mantle-cell lymphoma; PTCL, peripheral T-cell lymphoma.
