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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2016 Nov 11;78(6):1217–1223. doi: 10.1007/s00280-016-3180-x

Table 2.

Grade 3 or 4 Adverse Events

Adverse Event GPOH-HD-2002 Data for OEPA,
% (n=561)
HLHR13 Data for AEPA
(n=16)
Anemia 11.9% (67) 6.3% (1)
Leukopenia 70.5% (396) 75% (12)
Neutropenia 81.5% (457) 81.3% (13)
Thrombocytopenia 2.8% (16) 0%
Stomatitis 8.7% (49) 6.3% (1)
Constipation 7.3% (41) 0%
Neurotoxicity, sensory 1.3% (7) 0%
Neurotoxicity, motor 1.4% (8) 0%