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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2016 Nov 11;78(6):1217–1223. doi: 10.1007/s00280-016-3180-x

Table 4.

First Dose exposure measures. Geometric Mean (coefficient of variation).

ADC MMAE
Study; Dose Dose (mg/kg) n AUC
(days µg/mL)		 Cmax
(µg/mL)		 n AUC (days ng/mL) Cmax
(ng/mL)
Current Study
(actual)		 1.2 16 37.97 (18) 18.47 (14) 16 24.08 (24) 4.85 (16)
Current Study
(simulated)		 1.8 16 54.84 (18) 28.82 (14) 16 34.57 (24) 7.29 (16)
Fanale et al.
2012[2]		 1.2 12 40.52 (9)* --- 12 15.93 (60)* 3.12 (60)
Younes et al.
2010[9]		 1.2

1.8		 4

12		 46.14 (62)

79.41 (30)		 18.89 (27)

31.98 (29)		 4

12		 20.29 (212)

37.03 (47)		 2.72 (272)

4.97 (43)
Han et al. 2012
(Study 5)[15]		 1.2

1.8		 11

11		 52.77 (28)

89.84 (25)		 22.57 (23)

36.74 (34)		 14

14		 26.65 (71)

40.06 (53)		 4.11 (71)

4.98 (67)
*

AUC from day 0–7.