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MR signals acquired with high dose (D) and high time delay (TD) can cause an inaccurate estimation of the gadolinium concentration, such as the first-pass peak of the arterial input function (AIF) (a) and renal medulla in obstructive kidneys (b). The full lines in the plots are the true noiseless curves for the simulation, and the circles are multiple estimates from the simulated acquisition using D = 8 mL and TD = 800 ms.
