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. Author manuscript; available in PMC: 2017 Dec 27.
Published in final edited form as: Biochemistry. 2016 Dec 13;55(51):7043–7046. doi: 10.1021/acs.biochem.6b01127

Figure 1.

Figure 1

Overview of the TrpS catalytic cycle. The α-subunit (blue) cleaves IGP in a retroaldol reaction. Indole is channeled into the β-subunit (orange), where it reacts with L-Ser or L-Thr to generate L-Trp or β-MeTrp, respectively.