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. Author manuscript; available in PMC: 2017 Dec 27.
Published in final edited form as: Biochemistry. 2016 Dec 13;55(51):7043–7046. doi: 10.1021/acs.biochem.6b01127

Figure 3.

Figure 3

β-MeTrp binding within the PfTrpB. (a) Two of the four PfTrpB subunits within the asymmetric unit show β-MeTrp bound in a pose superimposable with the Trp-bound conformation (from PDB ID: 5DW3). Minor structural changes are observed only in regions that display conformational heterogeneity between subunits of the same crystal, including Q109 and D300. (b) One of the four PfTrpB subunits shows β-MeTrp in a novel pose. Hydrogen bond interactions are shown in yellow dashes. For reference, a single molecule of Trp has been superimposed (gray) to indicate the new pose in relation to the active site.